DNA - Science - Year 12: Biology SHE - LibGuides at Wilderness School

The Structure of DNA

DNA imaging made easy
Web article: 11 Mar 2018; Monica Marini
The forgotten scientist who paved the way for the discovery of DNA’s structure
Web article: 14 Nov 2017; J. Michael Creeth (The Conversation)
James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin
Biographies: n.d.; Science History Institute
The structure of DNA: Cooperation and competition
Web article: n.d.; Understanding Science team (University of California, Berkeley)

Enzyme Inhibitors | Antibodies

A near-universal way to measure enzyme inhibition Technique could offer new approach to drug discovery
Web article: 1 Mar 2018; Science Daily
Antibody Titer Test
Web article: 3 Jul 2017; Lydia Krause (reviewed by Elaine K Lou MD)
HIV Antibody Assays
Website: May 2006; Niel Constantine, PhD (UCSF Center for HIV Information)
Enzyme Inhibitors
Summary notes: n.d.; Sam Adam-Day (A Level Notes)
Monoclonal Antibodies
Web article: n.d.: Omudhome Ogbru (this websource has a LOT of advertising on it, but seems to be a reasonable jumping off point for this topic)

DNA extraction, analysis, sequencing, profiling...

Genome sequencing: A solution to India's problem of rare genetic diseases
Web article: 2 Nov 2019; The EconomicTimes - Prerna Katiyar
Understanding Direct-to-Consumer Genetic Testing.
Webpage: 12 Apr 2018; Merran Pearce
Study Finds Inaccuracies in 40 Percent of DTC Genetic Testing Results
Magazine article: 28 Mar 2018; The Scientist - Shawna Williams
Restriction Fragment Length Polymorphism (RFLP) Technique
Web article: 20 Jun 2016; Susha Cheriyedath, MSc
Genetic counselling difficulties and ethical implications of incidental findings from array-CGH: A 7-year national survey
PDF document: 22 Mar 2016; Mathilde Lefebvre, Damien Sanlaville, Nathalie Marle, Christel
Thauvin-Robinet, Élodie Gautier, Salima El Chehadeh, Anne-Laure
Mosca-Boidron, Julien Thevenon, Patrick Edery, Marie-Pierre Alex-Cordier,
et al.
‘Only a click away — DTC genetics for ancestry, health, love…and more: A view of the business and regulatory landscape’
Journal article: Mar 2016; Applied & Translational Genomics - Andelka M Phillips
Molecular cloning using polymerase chain reaction, an educational guide for cellular engineering
Journal article: 2015; Sayed Shahabuddin Hoseini, Martin G Sauer (Journal of Biological Engineering
The Biotechnology Revolution: PCR and the Use of Reverse Transcriptase to Clone Expressed Genes
Journal article: 2008; Leslie A. Pray
DTC Genetic Testing: 23andme, DNA Direct and Genelex
Journal article: 2008; Leslie Pray PhD
DTC Genetic Testing for Diabetes, Breast Cancer, Heart Disease and Paternity
Journal article: 2008; Karen Norrgards, PhD
Forensic DNA Profiling and Database
Journal article: Jul 2003; S Panneerchelvam, M.N. Norazmi (The Malaysian Journal of Medical Sciences)
DNA Technology in Forensic Science
Web article: 1992; The National Academy of Sciences
Plasmid Cloning by PCR
Webpage: n.d.; addgene
PCR Cloning Method
Webpage: n.d.; New England BioLabs

The Catalytic Properties of RNA

Evolution of three Nobel Prize themes and a Nobel snub theme in chemistry: a bibliometric study with focus on international collaboration
Journal article: 26 Apr 2017; Sichao Tong and Per Ahlgren (Springer Scientometrics)
Exploring the New RNA World
Web article: 3 Dec 2004; Thomas R Cech (Nobelprize.org)
Press Release: Ribonucleic acid (RNA) - a biomolecule of many functions
Press release: 12 Oct 1989; Nobelprize.org
The RNA World
Web article: 1989; Sidney Altman (Nobelprize.org)

Gene Therapy

What are the ethical issues surrounding gene therapy?
Webpage: 15 May 2018; Genetics Home Reference - US National Library of Medicine
Human, Social, and Environmental Impacts of Human Genetic Engineering
Journal article: 2015; Satyajit Patra, Araromi Adewale Andrew
Gene Therapy and Children
Web article: Apr 2014; Larissa Hirsch, MD
Moral and Ethical Issues in Gene Therapy
Web article: 14 Apr 2010; The Church of Scotland
Social Issues Raised by Gene Therapy
Web article: 1997; David King (base don a talk given at the annual meeting of the UK Gene Therapy Advisory Commission)
The Ethics of Gene Therapy
Web article: 1997; Emilie R Bergeson (while this article is now over 20 years old, it may help you to get an understanding of how things have changed/developed.)
Gene Therapy for Genetic Disorders
Web page: n.d.; American Society of Gene & Cell Therapy
Disease Treated by Gene Therapy
Web article: n.d.; D.A. Bleijs, PhD

Biotechnology - transgenic organisms, DNA manipulation, CRISPR, manufactured proteins

CRISPR: More than just for gene editing?
Web article: 11 Nov 2019; Phys.Org - Case Western Reserve University
Ethical Red Flags Fly As Russian Biologist Pushes Boundaries Of Gene Editing
Web article: 26 Oct 2019; RadioFreeEurope/RadioLiberty - Andy Heil
Skinny Genes: CRISPR Editing Staves Off Type 2 Diabetes, Obesity in Mice
Web article: 4 Sep 2019; Sputnik Society
Despite Controversy, Human Studies of CRISPR Move Forward in the U.S.
Web article: 13 Aug 2019; Scientific American - Karen Weintraub
CRISPR gene editing will be used inside humans for the first time
News article: 2 Aug 2019; 9News - Associated Press
In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder
Web article: 29 Jul 2019; NPR - Rob Stein
Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency
Web article: 12 Jul 2019; PHYS.ORG - Tufts University
Scientists genetically modify lizards using CRISPR-Cas9 gene editing tool
Web article: 7 Apr 2019; Slash Gear - Shane McGlaun
A controversial technology could save us from starvation — if we let it
Web article (sponsored): 12 Apr 2018; Erin Brodwin
‘Cut and Paste’ genome editing just got a little bit better
Blog post: 2 Mar 2018; Emi Schutz
Scientists create complex transmembrane proteins from scratch
Web article: 1 Mar 2018; University of Washington Health Sciences
Genome Editing
Webpage: 3 Aug 2017; National Human Genome Research Institute
Ethical issues of CRISPR technology and gene editing through the lens of solidarity
Journal article; 23 Feb 2017; John J. Mulvihill, Benjamin Capps, Yann Joly, Tamra Lysaght, Hub A. E. Zwart, Ruth Chadwick.
Designing Better Drugs
Web article: 15 Apr 2016; Wyss Institute - Harvard University
Ethical Issues in Genome Editing using Crispr/Cas9 System
Journal article: 24 Mar 2016; E Rodriguez
Synthetic biology’s clinical applications
Magazine article: 25 Sep 2015; Mike May
Ethical Considerations of Genetic Manipulation in Sport
Journal article: 27 May 2015; no author given
Genome editing poses ethical problems that we cannot ignore
Web article: 31 Mar 2015; Anthony Wrigley, Ainsley Newson
The ethical implications of a new gene editing technique
Webpage: 30 Mar 2015; Shouguang Jin
The Pros and Cons of Genetically Modified Organisms (GMOs)
Webpage: 24 Aug 2014; LabMate
Impacts of genetically modified animals on the ecosystem and human activities
Journal article: 12 Mar 2014; Louis-Marie Houdebline
GCSE Bitesize: Gene Technology
Study Notes: 2014; BBC
Where should we draw the line on ‘designer’ babies?
Web article: 18 Sep 2012; Lesley Chenoweth
Genetically Modified Organisms (GMOs): Transgenic Crops and Recombinant DNA Technology
Journal article: 2008; Theresa Phillips PhD
Genetic modification: The production of recombinant pharmaceutical proteins in plants
Journal article: Oct 2003; Julian K-C Ma, Pascal M W Drake, and Paul Christou
Genome editing CRISPR-Cas9. Biomedical and ethical considerations
Webpage: n.d.; Bioethics Research Library
What Are the PROS & CONS of Transgenic Crops
Webpage: n.d.: Arizona Genomics Institute - Arizona Genomics Computational Laboratory - Stanford University
Transgenic Organisms
Webpage: n.d.; lumen - Boundless Microbiology

Science - Year 12: Biology SHE: DNA

The Structure of DNA

Enzyme Inhibitors | Antibodies

DNA extraction, analysis, sequencing, profiling...

The Catalytic Properties of RNA

Gene Therapy

Biotechnology - transgenic organisms, DNA manipulation, CRISPR, manufactured proteins